Reaction Details Report a problem with these data
Target
N-formyl peptide receptor 2
Ligand
BDBM350523
Substrate
n/a
Meas. Tech.
FLIPR
EC50
363±n/a nM
Citation
 Viswanath, V; Beard, RL; Donello, JE; Hsia, E Use of agonists of formyl peptide receptor 2 for treating dermatological diseases US Patent  US10434112 Publication Date 10/8/2019 
Target
Name:
N-formyl peptide receptor 2
Synonyms:
ALXR, FPRL1, FPR2 | FMLP-related receptor I FMLP-R-I | FPR2 | FPR2_HUMAN | FPRH1 | FPRL1 | Formyl Peptide Receptor-Like 1 | HM63 | LXA4 receptor | LXA4R | Lipoxin A4 receptor | Lipoxin A4 receptor (LXA4) | RFP | hFPRL
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
38968.35
Organism:
Homo sapiens (Human)
Description:
P25090
Residue:
351
Sequence:
METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
  
Inhibitor
Name:
BDBM350523
Synonyms:
1-(8-methyl-2,4-dioxo-1,3- diazaspiro[4,5]decan-3-yl)-3- (p-tolypurea | US10208071, Table 2.4 | US10434112, Table 2.4 | US10799518, Structure TABLE 2.4
Type:
Small organic molecule
Emp. Form.:
C17H22N4O3
Mol. Mass.:
330.3816
SMILES:
CC1CCC2(CC1)NC(=O)N(NC(=O)Nc1ccc(C)cc1)C2=O |(-6.85,-3.59,;-5.76,-2.5,;-6.16,-1.01,;-5.07,.08,;-3.58,-.32,;-3.19,-1.81,;-4.27,-2.9,;-4.06,1.14,;-2.81,2.05,;-2.81,3.59,;-1.57,1.14,;-.08,1.54,;1.01,.45,;.61,-1.03,;2.5,.85,;3.58,-.24,;3.19,-1.73,;4.27,-2.81,;5.76,-2.42,;6.85,-3.5,;6.16,-.93,;5.07,.16,;-2.04,-.32,;-1.27,-1.66,)|
Structure:
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