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TargetJAK2 (aa 828-1132)
LigandBDBM380441
Substrate/Competitorn/a
Meas. Tech.In Vitro JAK Kinase Assay
IC50>1000±n/a nM
Citation Li, YZhuo, JQian, DMei, S Bipyrazole derivatives as JAK inhibitors US Patent US10435392 Publication Date 10/8/2019
More Info.:Get all data from this article,  Assay Method
 
JAK2 (aa 828-1132)
Name:JAK2 (aa 828-1132)
Synonyms:Tyrosine-protein kinase JAK2
Type:n/a
Mol. Mass.:35579.28
Organism:Homo sapiens (Human)
Description:n/a
Residue:305
Sequence:
GALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHS
TEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKER
IDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEY
YKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGN
DKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIR
DNMAG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM380441
NameBDBM380441
Synonyms:4-[3-(1H,1′H-4,4′-Bipyrazol-1-yl)-3-(cyanomethyl)azetidin-1-yl]-2,5-difluoro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]benzamide trifluoroacetate | US10435392, Example 5 | US9926301, Example 5
TypeSmall organic molecule
Emp. Form.C21H18F5N7O
Mol. Mass.479.4059
SMILESC[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(cn1)-c1cn[nH]c1)C(F)(F)F |r|
Structure
n/a