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TargetJAK2 (aa 828-1132)
LigandBDBM246853
Substrate/Competitorn/a
Meas. Tech.In Vitro JAK Kinase Assay
IC50 650±n/a nM
Citation Li, YZhuo, JQian, DMei, S Bipyrazole derivatives as JAK inhibitors US Patent US10435392 Publication Date 10/8/2019
More Info.:Get all data from this article,  Assay Method
 
JAK2 (aa 828-1132)
Name:JAK2 (aa 828-1132)
Synonyms:Tyrosine-protein kinase JAK2
Type:n/a
Mol. Mass.:35579.28
Organism:Homo sapiens (Human)
Description:O60674[828-1132]
Residue:305
Sequence:
GALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHS
TEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKER
IDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEY
YKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGN
DKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIR
DNMAG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM246853
NameBDBM246853
Synonyms:4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,1'H-4,4'- bipyrazol-1- yl)azetidin-1-yl]-2,5- difluoro-N-[(1S)- 2,2,2-trifluoro-1- methylethyl] benzamide | US10053465, 2 | US10065963, Compound 2 | US10125150, Example 2 | US10336759, # 2 | US10435392, Example 17 | US10479803, Example 2D | US10519163, Example 2 | US10675284, Example 2 | US11084822, Example 2 | US11130767, # 2 | US11136326, Example 2 | US9732097, Example 2 | US9926301, Example 17
TypeSmall organic molecule
Emp. Form.C23H22F5N7O
Mol. Mass.507.4591
SMILESC[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(cn1)-c1c(C)n[nH]c1C)C(F)(F)F |r|
Structure
n/a