Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM414505
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
19.0±n/a nM
Citation
 Kuduk, SD; Liverton, N; Luo, Y Oxazole orexin receptor antagonists US Patent  US10435398 Publication Date 10/8/2019 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM414505
Synonyms:
N-Ethyl-N-{2-[4-(1-hydroxy-1-methylpropyl)-5-methyl-1,3-oxazol-2-yl]ethyl}-2-(2H-1,2,3-triazol-2-yl)benzamide | US10435398, Example 19 | US10435398, Example 20
Type:
Small organic molecule
Emp. Form.:
C20H24N6O4
Mol. Mass.:
412.4424
SMILES:
CCN(CCc1nc(C(=O)N(C)OC)c(C)o1)C(=O)c1ccccc1-n1nccn1
Structure:
Search PDB for entries with ligand similarity: