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Target
Mitogen-activated protein kinase kinase kinase kinase 1
Ligand
BDBM414797
Substrate
n/a
Meas. Tech.
HPK1 Kinase Binding Assay
Ki
<100±n/a nM
Citation
 Vechorkin, O; Liu, K; Sokolsky, A; Wang, A; Ye, HF; Ye, Q; Yao, W Pyrazolopyridine compounds and uses thereof US Patent  US10435405 Publication Date 10/8/2019 
Target
Name:
Mitogen-activated protein kinase kinase kinase kinase 1
Synonyms:
HPK1 | M4K1_HUMAN | MAP4K1
Type:
PROTEIN
Mol. Mass.:
91316.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586597
Residue:
833
Sequence:
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
  
Inhibitor
Name:
BDBM414797
Synonyms:
US10435405, Example 214 | US10934288, Example 214
Type:
Small organic molecule
Emp. Form.:
C22H22F2N6O
Mol. Mass.:
424.4465
SMILES:
CNC1CCc2cc(F)c(c(F)c2C1)-c1ncc2[nH]nc(-c3cnn(C)c3)c2c1OC |(1.57,5.64,;.08,6.04,;-1.01,4.95,;-2.5,5.35,;-3.59,4.26,;-3.19,2.77,;-4.28,1.68,;-3.88,.2,;-4.97,-.89,;-2.39,-.2,;-1.3,.89,;.18,.49,;-1.7,2.37,;-.61,3.46,;-1.99,-1.69,;-3.08,-2.78,;-2.68,-4.27,;-1.2,-4.67,;-.5,-6.04,;1.02,-5.8,;1.26,-4.28,;2.6,-3.51,;4.06,-3.98,;4.97,-2.74,;4.06,-1.49,;4.83,-.16,;2.6,-1.97,;-.11,-3.58,;-.51,-2.09,;.58,-1,;2.07,-1.4,)|
Structure:
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