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Target
Tyrosine-protein kinase JAK2
Ligand
BDBM230110
Substrate
n/a
Meas. Tech.
Jak2 Tyrosine Kinase Assay
IC50
630±n/a nM
Citation
 Batt, DG; Bertrand, MB; De Lucca, GV; Galella, MA; Ko, SS; Langevine, CM; Liu, Q; Shi, Q; Srivastava, AS; Tino, JA; Watterson, SH Substituted tetrahydrocarbazole and carbazole carboxamide compounds US Patent  US10435415 Publication Date 10/8/2019 
Target
Name:
Tyrosine-protein kinase JAK2
Synonyms:
JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase)
Type:
Protein
Mol. Mass.:
130684.68
Organism:
Homo sapiens (Human)
Description:
O60674
Residue:
1132
Sequence:
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM230110
Synonyms:
US10106559, Example 37 | US10435415, Example 37 | US9334290, 37 | US9850258, Example 37
Type:
Small organic molecule
Emp. Form.:
C32H27ClN4O5
Mol. Mass.:
583.034
SMILES:
COc1cccn2c1cc(=O)n(-c1cccc(c1C)-c1c(Cl)cc(C(N)=O)c3[nH]c4cc(ccc4c13)C(C)(C)O)c2=O |(8.37,-7.31,;7.03,-6.54,;7.03,-5,;8.37,-4.23,;8.37,-2.69,;7.03,-1.92,;5.7,-2.69,;5.7,-4.23,;4.37,-5,;3.03,-4.23,;1.7,-5,;3.03,-2.69,;1.7,-1.93,;.37,-2.69,;-.97,-1.93,;-.97,-.38,;.37,.38,;1.7,-.38,;3.03,.38,;.37,1.93,;1.7,2.69,;3.03,1.93,;1.7,4.23,;.37,5,;.37,6.54,;1.7,7.31,;-.97,7.31,;-.97,4.23,;-2.43,4.71,;-3.34,3.47,;-4.87,3.3,;-5.49,1.9,;-4.59,.65,;-3.06,.81,;-2.43,2.22,;-.97,2.69,;-7.03,1.9,;-6.64,.41,;-8.37,1.13,;-7.8,3.23,;4.37,-1.93,;4.37,-.38,)|
Structure:
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