Reaction Details Report a problem with these data
Target
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Ligand
BDBM414834
Substrate
n/a
Meas. Tech.
Isothermal Titration Calorimetry
Kd
190±n/a nM
Citation
 Buchstaller, H Piperidinyl derivatives US Patent  US10428024 Publication Date 10/1/2019 
Target
Name:
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Synonyms:
PDHK2 | PDK2 | PDK2_HUMAN | Pyruvate dehydrogenase kinase 2 (PDK2) | Pyruvate dehydrogenase kinase isoenzyme 1 (PDK2)
Type:
Enzyme
Mol. Mass.:
46153.78
Organism:
Homo sapiens (Human)
Description:
Q15119
Residue:
407
Sequence:
MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
  
Inhibitor
Name:
BDBM414834
Synonyms:
1-((R)-3,3,3-Trifluoro-2-hydroxy-2-methyl-propionyl)-piperidine-4-carboxylic acid (4-chloro-phenyl)-methyl-amide | US10428024, Compound A5
Type:
Small organic molecule
Emp. Form.:
C17H20ClF3N2O3
Mol. Mass.:
392.801
SMILES:
CN(C(=O)C1CCN(CC1)C(=O)[C@@](C)(O)C(F)(F)F)c1ccc(Cl)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: