Reaction Details
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Tyrosine-protein kinase SYK [360-635]
Ligand
BDBM295266
Substrate
n/a
Meas. Tech.
SYK Assa
pH
7.5±n/a
IC50
373±n/a nM
Comments
extracted
Citation
Bhagirath, N; Kennedy-Smith, J; Le, NT; Lucas, MC; Padilla, F; Soth, M Inhibitors of SYK US Patent US10112928 Publication Date 10/30/2018 More Info.:
Target
Name:
Tyrosine-protein kinase SYK [360-635]
Synonyms:
KSYK_HUMAN | SYK | SYK RPA purified, truncated construct of Spleen Tyrosine Kinase (aa 360-635) | Tyrosine-protein kinase SYK | recombinant human SYK(aa 360-635)
Type:
n/a
Mol. Mass.:
31987.15
Organism:
Homo sapiens (Human)
Description:
Human MetAP2 protein from a culture superatant of insect cells (sf9) infected with MetAP2 recombinant baculovirus
Residue:
276
Sequence:
PKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
Inhibitor
Name:
BDBM295266
Synonyms:
4-(6-methylpyridin-2- ylamino)-6-(o- tolyloxy)pyridazine- 3-carboxamide | US10112928, Compound I-8
Type:
Small organic molecule
Emp. Form.:
C18H17N5O2
Mol. Mass.:
335.3599
SMILES:
Cc1cccc(Nc2cc(Oc3ccccc3C)nnc2C(N)=O)n1
Structure:
