Reaction Details Report a problem with these data
Target
Mitotic checkpoint serine/threonine-protein kinase BUB1 [704-1085]
Ligand
BDBM415414
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
18.3±n/a nM
Citation
 Graham, K; Klar, U; Briem, H; Schulze, V; Siemeister, G; Lienau, P; Tempel, R; Bálint, J 4H-pyrrolo[3,2-C]pyridin-4-one derivatives US Patent  US10428063 Publication Date 10/1/2019 
Target
Name:
Mitotic checkpoint serine/threonine-protein kinase BUB1 [704-1085]
Synonyms:
BUB1 | BUB1L | BUB1_HUMAN | Mitotic checkpoint serine/threonine-protein kinase BUB1 (aa 704-1085)
Type:
n/a
Mol. Mass.:
43624.72
Organism:
Homo sapiens (Human)
Description:
O43683[704-1085]
Residue:
382
Sequence:
DAAIAEDPPDAIAGLQAEWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMERLKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFRRLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLECKRSRK
  
Inhibitor
Name:
BDBM415414
Synonyms:
Example 14 (N-{4-[4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]pyridin-2-yl}acetamide) | US10428063, Example 14 | US20230322767, Example No. 14 WO 2016/120196 | US20230339939, WO 2016/120196, Example 14 | WO 2016/120196, Example 14
Type:
Small organic molecule
Emp. Form.:
C20H19N5O2
Mol. Mass.:
361.3972
SMILES:
CC(=O)Nc1cc(ccn1)-c1[nH]c2CCNC(=O)c2c1Nc1ccccc1
Structure:
Search PDB for entries with ligand similarity: