Reaction Details Report a problem with these data
Target
Mitotic checkpoint serine/threonine-protein kinase BUB1 [704-1085]
Ligand
BDBM415433
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
51.8±n/a nM
Citation
 Graham, K; Klar, U; Briem, H; Schulze, V; Siemeister, G; Lienau, P; Tempel, R; Bálint, J 4H-pyrrolo[3,2-C]pyridin-4-one derivatives US Patent  US10428063 Publication Date 10/1/2019 
Target
Name:
Mitotic checkpoint serine/threonine-protein kinase BUB1 [704-1085]
Synonyms:
BUB1 | BUB1L | BUB1_HUMAN | Mitotic checkpoint serine/threonine-protein kinase BUB1 (aa 704-1085)
Type:
n/a
Mol. Mass.:
43624.72
Organism:
Homo sapiens (Human)
Description:
O43683[704-1085]
Residue:
382
Sequence:
DAAIAEDPPDAIAGLQAEWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMERLKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFRRLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLECKRSRK
  
Inhibitor
Name:
BDBM415433
Synonyms:
5-methyl-3-(phenylamino)-2-[3-(3,3,3-trifluoropropoxy)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one | US10428063, Example 33
Type:
Small organic molecule
Emp. Form.:
C22H21F3N4O2
Mol. Mass.:
430.4229
SMILES:
CN1CCc2[nH]c(c(Nc3ccccc3)c2C1=O)-c1ccncc1OCCC(F)(F)F
Structure:
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