Target
Serine protease HTRA1
Ligand
BDBM415653
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
30.0±n/a nM
Citation
 Hornsperger, BIacone, RKitas, EAMaerki, HPReutlinger, MMohr, P Difluoroketamide derivatives US Patent  US10428108 Publication Date 10/1/2019 
Target
Name:
Serine protease HTRA1
Synonyms:
HTRA | HTRA1 | HTRA1_HUMAN | PRSS11
Type:
Protein
Mol. Mass.:
51293.95
Organism:
Homo sapiens (Human)
Description:
Q92743
Residue:
480
Sequence:
MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARDACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
  
Inhibitor
Name:
BDBM415653
Synonyms:
US10428108, Example 63
Type:
Small organic molecule
Emp. Form.:
C26H25ClF5N3O4
Mol. Mass.:
573.939
SMILES:
CC(C)[C@H](NC(=O)[C@@H](NC(=O)\C=C\c1cccc(Cl)c1)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F |r|
Structure:
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