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Target
Serine protease HTRA1
Ligand
BDBM415681
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
50.0±n/a nM
Citation
 Hornsperger, B; Iacone, R; Kitas, EA; Maerki, HP; Reutlinger, M; Mohr, P Difluoroketamide derivatives US Patent  US10428108 Publication Date 10/1/2019 
Target
Name:
Serine protease HTRA1
Synonyms:
HTRA | HTRA1 | HTRA1_HUMAN | PRSS11
Type:
Protein
Mol. Mass.:
51293.95
Organism:
Homo sapiens (Human)
Description:
Q92743
Residue:
480
Sequence:
MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARDACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
  
Inhibitor
Name:
BDBM415681
Synonyms:
US10428108, Example 90
Type:
Small organic molecule
Emp. Form.:
C32H31ClF5N3O5
Mol. Mass.:
668.051
SMILES:
CC(C)[C@H](NC(=O)[C@@H](NC(=O)C[C@@H](Oc1cccc(Cl)c1)c1ccccc1)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F |r|
Structure:
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