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Target
Bromodomain-containing protein 4 [42-168]
Ligand
BDBM343523
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
<1000±n/a nM
Citation
 Rodgers, JD; Shepard, S; Wang, H; Shao, L Tricyclic heterocycles as bet protein inhibitors US Patent  US10442803 Publication Date 10/15/2019 
Target
Name:
Bromodomain-containing protein 4 [42-168]
Synonyms:
BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
15054.68
Organism:
Homo sapiens (Human)
Description:
O60885[42-168]
Residue:
127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Inhibitor
Name:
BDBM343523
Synonyms:
US10442803, Example 122 | US11091484, Example 122 | US9777003, Example 122
Type:
Small organic molecule
Emp. Form.:
C22H24N6O
Mol. Mass.:
388.4656
SMILES:
CNC(=O)c1cc2c(ccc3nnc(C)n23)n1Cc1cccc(CN2CCC2)c1
Structure:
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