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Target
Bromodomain-containing protein 4 [342-460]
Ligand
BDBM343561
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
<1000±n/a nM
Citation
 Rodgers, JD; Shepard, S; Wang, H; Shao, L Tricyclic heterocycles as bet protein inhibitors US Patent  US10442803 Publication Date 10/15/2019 
Target
Name:
Bromodomain-containing protein 4 [342-460]
Synonyms:
BRD4 | BRD4-BD2 (aa 342-460) | BRD4_HUMAN | Bromodomain containing 4 (aa 342-460) | Bromodomain-containing protein 4 (BRD4)(BD2) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13783.81
Organism:
Homo sapiens (Human)
Description:
a.a. 342-460 (BRD4-BD2)
Residue:
119
Sequence:
PAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
  
Inhibitor
Name:
BDBM343561
Synonyms:
US10442803, Example 160 | US11091484, Example 160 | US9777003, Example 160
Type:
Small organic molecule
Emp. Form.:
C24H24ClN7
Mol. Mass.:
445.947
SMILES:
CCN1CC(C1)n1ccc(n1)-c1cc2c(ccc3nnc(C)n23)n1Cc1cccc(Cl)c1
Structure:
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