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Target
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 [329-824]
Ligand
BDBM415749
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
0.009±n/a nM
Citation
 Soldermann, CP; Quancard, J; Schlapbach, A; Simic, O; Tintelnot-Blomley, M; Zoller, T Pyrazolo pyrimidine derivatives and their use as MALT1 inhbitors US Patent  US10442808 Publication Date 10/15/2019 
Target
Name:
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 [329-824]
Synonyms:
MALT1 | MALT1_HUMAN | MLT | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1)(aa 329-824)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55563.19
Organism:
Homo sapiens (Human)
Description:
amino acids 329-824
Residue:
495
Sequence:
NKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
  
Inhibitor
Name:
BDBM415749
Synonyms:
1-(3-chloro-4-(3- (hydroxymethyl)-5- methyl-1H-pyrazol- 1-yl)phenyl)-3-(2- chloro-7- isopropylpyrazolo[1, 5-a]pyrimidin-6- yl)urea | US10442808, Example 28
Type:
Small organic molecule
Emp. Form.:
C21H21Cl2N7O2
Mol. Mass.:
474.343
SMILES:
CC(C)c1c(NC(=O)Nc2ccc(c(Cl)c2)-n2nc(CO)cc2C)cnc2cc(Cl)nn12
Structure:
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