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Target
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 [329-824]
Ligand
BDBM355913
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
0.011±n/a nM
Citation
 Soldermann, CP; Quancard, J; Schlapbach, A; Simic, O; Tintelnot-Blomley, M; Zoller, T Pyrazolo pyrimidine derivatives and their use as MALT1 inhbitors US Patent  US10442808 Publication Date 10/15/2019 
Target
Name:
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 [329-824]
Synonyms:
MALT1 | MALT1_HUMAN | MLT | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1)(aa 329-824)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55563.19
Organism:
Homo sapiens (Human)
Description:
amino acids 329-824
Residue:
495
Sequence:
NKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
  
Inhibitor
Name:
BDBM355913
Synonyms:
(R)-1-(2-chloro-7-(1- methoxy-2- methylpropyl)pyra- zolo[1,5-a]pyrimidin-6- yl)-3-(2- (trifluoromethyl)pyridin- 4-yl)urea | US10442808, Example 37 | US9815842, Example 37
Type:
Small organic molecule
Emp. Form.:
C18H18ClF3N6O2
Mol. Mass.:
442.823
SMILES:
CO[C@H](C(C)C)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12 |r|
Structure:
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