Reaction Details
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Mucosa-associated lymphoid tissue lymphoma translocation protein 1 [329-824]
Ligand
BDBM415905
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
0.080±n/a nM
Citation
Soldermann, CP; Quancard, J; Schlapbach, A; Simic, O; Tintelnot-Blomley, M; Zoller, T Pyrazolo pyrimidine derivatives and their use as MALT1 inhbitors US Patent US10442808 Publication Date 10/15/2019 More Info.:
Target
Name:
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 [329-824]
Synonyms:
MALT1 | MALT1_HUMAN | MLT | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1)(aa 329-824)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55563.19
Organism:
Homo sapiens (Human)
Description:
amino acids 329-824
Residue:
495
Sequence:
NKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
Inhibitor
Name:
BDBM415905
Synonyms:
1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-yl)-3-(2- chloro-7-(1-methyl- 1H-imidazol-2- yl)pyrazolo[1,5- a]pyrimidin-6-yl)urea | US10442808, Example 86
Type:
Small organic molecule
Emp. Form.:
C18H13Cl2N11O
Mol. Mass.:
470.275
SMILES:
Cn1ccnc1-c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12 |(-6.48,2.27,;-5.14,3.04,;-4.67,4.5,;-3.13,4.5,;-2.65,3.04,;-3.9,2.13,;-3.9,.59,;-2.56,-.18,;-1.23,.59,;.1,-.18,;.1,-1.72,;1.44,.59,;2.77,-.18,;2.77,-1.72,;4.1,-2.49,;5.44,-1.72,;5.44,-.18,;6.77,.59,;4.1,.59,;6.77,-2.49,;6.77,-4.03,;8.24,-4.5,;9.14,-3.26,;8.24,-2.01,;-2.56,-1.72,;-3.9,-2.49,;-5.23,-1.72,;-6.7,-2.19,;-7.6,-.95,;-9.14,-.95,;-6.7,.3,;-5.23,-.18,)|
Structure:
