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Target
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 [329-824]
Ligand
BDBM355994
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
0.028±n/a nM
Citation
 Soldermann, CP; Quancard, J; Schlapbach, A; Simic, O; Tintelnot-Blomley, M; Zoller, T Pyrazolo pyrimidine derivatives and their use as MALT1 inhbitors US Patent  US10442808 Publication Date 10/15/2019 
Target
Name:
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 [329-824]
Synonyms:
MALT1 | MALT1_HUMAN | MLT | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1)(aa 329-824)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55563.19
Organism:
Homo sapiens (Human)
Description:
amino acids 329-824
Residue:
495
Sequence:
NKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
  
Inhibitor
Name:
BDBM355994
Synonyms:
1-(6-(4-(aminomethyl)-1H-pyrazol-1-yl)-5-chloropyridin-3-yl)-3-(2-chloro-7-isopropylpyrazolo[1,5-a]pyrimidin-6-yl)urea | US10442808, Example 118 | US9815842, Example 118
Type:
Small organic molecule
Emp. Form.:
C19H19Cl2N9O
Mol. Mass.:
460.32
SMILES:
CC(C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2cc(CN)cn2)cnc2cc(Cl)nn12
Structure:
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