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Target
Apoptosis regulator Bcl-2
Ligand
BDBM417044
Substrate
n/a
Meas. Tech.
Bcl-2 Competition Binding (Fluorescence Polarization) Assay
IC50
<10.00±n/a nM
Citation
 Chen, Y; Lou, Y BCL-2 inhibitors US Patent  US10377755 Publication Date 8/13/2019 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM417044
Synonyms:
4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-(((4-fluoro-1-(oxetan-3-yl)piperidin-4-yl)methyl)amino)-3-nitrophenyl)sulfonyl)-2-(pyrazolo[4,3-b]pyrrolo[3,2-e]pyridin-1(5H)-yl)benzamide | US10377755, Example 14
Type:
Small organic molecule
Emp. Form.:
C49H54ClFN10O6S
Mol. Mass.:
965.533
SMILES:
CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4(F)CCN(CC4)C4COC4)c(c3)[N+]([O-])=O)c(c2)-n2ncc3nc4[nH]ccc4cc23)=C(C1)c1ccc(Cl)cc1 |c:66|
Structure:
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