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Target
Metabotropic glutamate receptor 2
Ligand
BDBM417110
Substrate
n/a
Meas. Tech.
mGlu2 Ca2+ Flux Assay
IC50
>30000±n/a nM
Citation
 Conn, PJ; Lindsley, CW; Emmitte, KA; Engers, JL; Bollinger, KA; Breiner, MM Negative allosteric modulators of metabotropic glutamate receptor 3 US Patent  US10399948 Publication Date 9/3/2019 
Target
Name:
Metabotropic glutamate receptor 2
Synonyms:
GRM2_RAT | Gprc1b | Grm2 | Mglur2
Type:
PROTEIN
Mol. Mass.:
95786.41
Organism:
Rattus norvegicus
Description:
ChEMBL_105034
Residue:
872
Sequence:
MESLLGFLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHSDAPTAVTGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEERFHCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTHLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSFIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFVFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAPRASANLGQGSGSQFVPTVCNGREVVDSTTSSL
  
Inhibitor
Name:
BDBM417110
Synonyms:
2-(2-((1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin-4-yl)oxy)ethoxy)nicotinonitrile | US10399948, Compound 56
Type:
Small organic molecule
Emp. Form.:
C19H14FN3O3
Mol. Mass.:
351.3312
SMILES:
Fc1ccc(cc1)-n1ccc(OCCOc2ncccc2C#N)cc1=O
Structure:
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