Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM397128
Substrate
n/a
Meas. Tech.
Measurement of Human α7 Nicotinic Acetylcholine Receptor (nAChR)'s Activity
EC50
300±n/a nM
Citation
 Maeng, CYJang, YKCha, SBShin, HWJoung, CMYi, EJ Pharmaceutical composition comprising pyridone derivatives US Patent  US10456385 Publication Date 10/29/2019 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM397128
Synonyms:
N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-1-[5-tert-butyl-2-thiazolyl]-6-oxo-3-pyridinecarboxamide | US10456385, Example 21 | US9987259, Example 21
Type:
Small organic molecule
Emp. Form.:
C20H26N4O2S
Mol. Mass.:
386.511
SMILES:
CC(C)(C)c1cnc(s1)-n1cc(ccc1=O)C(=O)N[C@H]1CN2CCC1CC2 |r,wU:19.20,(-7.67,2.49,;-6.9,1.15,;-7.67,-.18,;-6.13,2.49,;-5.36,1.15,;-4.46,2.4,;-2.99,1.92,;-2.99,.38,;-4.46,-.09,;-1.66,-.39,;-.33,.38,;1.01,-.39,;1.01,-1.93,;-.33,-2.7,;-1.66,-1.93,;-2.99,-2.7,;2.34,.38,;2.34,1.92,;3.67,-.39,;5.01,.38,;5.01,1.93,;6.34,2.7,;7.67,1.93,;7.67,.38,;6.34,-.39,;7.06,.96,;5.57,1.36,)|
Structure:
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