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Target
Histone deacetylase 1
Ligand
BDBM417121
Substrate
n/a
Meas. Tech.
HDAC Enzyme Activity Inhibition Assay (In Vitro)
IC50
7935±25 nM
Citation
 Kozikowski, A; Shen, S; Bergman, J; Gaisina, I Tetrahydroquinoline substituted hydroxamic acids as selective histone deacetylase 6 inhibitors US Patent  US10456394 Publication Date 10/29/2019 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM417121
Synonyms:
US10456394, Example 16
Type:
Small organic molecule
Emp. Form.:
C16H16N2O2S
Mol. Mass.:
300.375
SMILES:
ONC(=O)c1ccc(CN2CCSc3ccccc23)cc1
Structure:
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