Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM419113
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
>10000±n/a nM
Citation
 Gobbi, L; Grether, U; Guba, W; Kretz, J; Martin, RE; Westphal, MV; Ijzerman, AP [1,2,3]triazolo[4,5-D]pyrimidine derivatives US Patent  US10450321 Publication Date 10/22/2019 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM419113
Synonyms:
2-({5-tert-Butyl-7-[(3S)-3-hydroxypyrrolidin-1-yl]-2H-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl}methyl)benzene-1-sulfonyl fluoride | US10450321, Example 1
Type:
Small organic molecule
Emp. Form.:
C19H23FN6O
Mol. Mass.:
370.4239
SMILES:
CC(C)(C)c1nc(N2CC[C@H](O)C2)c2nn(Cc3ccccc3F)nc2n1 |r|
Structure:
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