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Target
Nuclear receptor ROR-gamma
Ligand
BDBM419181
Substrate
n/a
Meas. Tech.
GAL4-RORgamma Transactivation
IC50
>1000±n/a nM
Citation
 Musicki, B; Bouix-Peter, C; Ouvry, G; Thoreau, E Benzenesulfonamide derivatives as inverse agonists of retinoid-related orphan receptor gamma (RORγ(T)) US Patent  US10457637 Publication Date 10/29/2019 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM419181
Synonyms:
N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonimidoyl)-4-((1- (methylsulfonylpiperidin-4- yl)methoxy)benzene- sulfonamide | US10457637, Compound 51
Type:
Small organic molecule
Emp. Form.:
C26H39N3O6S3
Mol. Mass.:
585.799
SMILES:
CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCN(CC2)S(C)(=O)=O)c(c1)S(C)(=N)=O
Structure:
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