Reaction Details Report a problem with these data
Target
D-amino-acid oxidase
Ligand
BDBM210778
Substrate
n/a
Meas. Tech.
In Vitro DAAO Enzyme Assay
IC50
22.0±n/a nM
Citation
 Farnaby, W; Fieldhouse, C; Hazel, K; Kerr, C; Kinsella, N; Livermore, D; Merchant, K; Miller, D Pyridazinone compounds and their use as DAAO inhibitors US Patent  US10463663 Publication Date 11/5/2019 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN
Type:
Homodimer
Mol. Mass.:
39476.06
Organism:
Homo sapiens (Human)
Description:
P14920
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
  
Inhibitor
Name:
BDBM210778
Synonyms:
US10463663, Example 10 | US11129828, Example 26 | US9290456, 10 | US9290456, 26 | US9931340, Example 26
Type:
Small organic molecule
Emp. Form.:
C13H11F3N2O3
Mol. Mass.:
300.2332
SMILES:
Oc1cc(CCc2cccc(OC(F)(F)F)c2)n[nH]c1=O
Structure:
Search PDB for entries with ligand similarity: