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Target
Heat shock protein HSP 90-alpha
Ligand
BDBM419559
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
IC50
383±n/a nM
Citation
 Seo, YH Compound having HSP90 inhibitory activity or pharmaceutically acceptable salt thereof, and medical use thereof US Patent  US10464907 Publication Date 11/5/2019 
Target
Name:
Heat shock protein HSP 90-alpha
Synonyms:
HS90A_BOVIN | HSP90A | HSP90AA1 | HSPCA
Type:
Protein
Mol. Mass.:
84693.47
Organism:
Bovine
Description:
Q76LV2
Residue:
733
Sequence:
MPEETQAQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESDDKPEIEDVGSDEEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDSSAAVTEEMPPLEGDDDTSRMEEVD
  
Inhibitor
Name:
BDBM419559
Synonyms:
US10464907, Compound 11c | US10889552, Compound 11c
Type:
Small organic molecule
Emp. Form.:
C11H12ClNO4
Mol. Mass.:
257.67
SMILES:
Oc1cc(O)c(cc1Cl)C(=O)N1CCOCC1
Structure:
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