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Target
Cyclin-dependent kinase 6
Ligand
BDBM419869
Substrate
n/a
Meas. Tech.
Caliper Mobility Shift Assay
IC50
60±n/a nM
Citation
 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X 2,4-disubstituted pyrimidines as CDK inhibitors US Patent  US10464927 Publication Date 11/5/2019 
Target
Name:
Cyclin-dependent kinase 6
Synonyms:
CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE
Type:
Enzyme Subunit
Mol. Mass.:
36937.42
Organism:
Homo sapiens (Human)
Description:
Q00534
Residue:
326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
  
Inhibitor
Name:
BDBM419869
Synonyms:
US10464927, Compound I-17
Type:
Small organic molecule
Emp. Form.:
C32H35FN8
Mol. Mass.:
550.6723
SMILES:
CC(C)c1c(C#N)n(C2CC2)c2ccc(cc12)-c1nc(Nc2ccc(CN3CCN(CC3)C3CC3)cn2)ncc1F
Structure:
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