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Target
Cyclin-dependent kinase 4
Ligand
BDBM419874
Substrate
n/a
Meas. Tech.
Caliper Mobility Shift Assay
IC50
<20±n/a nM
Citation
 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X 2,4-disubstituted pyrimidines as CDK inhibitors US Patent  US10464927 Publication Date 11/5/2019 
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM419874
Synonyms:
US10464927, Compound I-22
Type:
Small organic molecule
Emp. Form.:
C32H39FN8O
Mol. Mass.:
570.7035
SMILES:
CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4n(C5CCCC5)c(cc4c3)C(=O)N(C)C)nc2)CC1
Structure:
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