Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 4
Ligand
BDBM419891
Substrate
n/a
Meas. Tech.
Caliper Mobility Shift Assay
IC50
<20±n/a nM
Citation
 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X 2,4-disubstituted pyrimidines as CDK inhibitors US Patent  US10464927 Publication Date 11/5/2019 
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM419891
Synonyms:
US10464927, Compound I-39
Type:
Small organic molecule
Emp. Form.:
C28H37FN10
Mol. Mass.:
532.6588
SMILES:
CCC(CC)n1c(nc2cnc(nc12)-c1nc(Nc2ccc(CN3CCN(C)CC3)cn2)ncc1F)C(C)C
Structure:
Search PDB for entries with ligand similarity: