Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 4
Ligand
BDBM419897
Substrate
n/a
Meas. Tech.
Caliper Mobility Shift Assay
IC50
60±n/a nM
Citation
 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X 2,4-disubstituted pyrimidines as CDK inhibitors US Patent  US10464927 Publication Date 11/5/2019 
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM419897
Synonyms:
US10464927, Compound I-45
Type:
Small organic molecule
Emp. Form.:
C29H34F2N8
Mol. Mass.:
532.6307
SMILES:
CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4n(nc(C)c4c3F)C3CCCC3)nc2)CC1
Structure:
Search PDB for entries with ligand similarity: