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Target
Bromodomain-containing protein 4 [42-168]
Ligand
BDBM318586
Substrate
n/a
Meas. Tech.
AlphaScreen Assay A2
IC50
<100±n/a nM
Citation
 Combs, AP; Sparks, RB; Maduskuie, Jr., TP; Rodgers, JD Tricyclic heterocycles as BET protein inhibitors US Patent  US10464947 Publication Date 11/5/2019 
Target
Name:
Bromodomain-containing protein 4 [42-168]
Synonyms:
BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
15054.68
Organism:
Homo sapiens (Human)
Description:
O60885[42-168]
Residue:
127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Inhibitor
Name:
BDBM318586
Synonyms:
4-[2-(Aminomethyl)pyridin-3-yl]-7-(3,5-dimethylisoxazol-4-yl)-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2(1H)-one bis(trifluoroacetate) | US10464947, Example 130 | US11498926, Example 130 | US9624241, Example 130
Type:
Small organic molecule
Emp. Form.:
C20H19N5O3
Mol. Mass.:
377.3966
SMILES:
Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1cccnc1CN |(.13,-2.67,;1.47,-3.44,;1.94,-4.91,;3.48,-4.91,;3.96,-3.44,;5.29,-2.67,;2.71,-2.54,;2.71,-1,;4.04,-.23,;4.04,1.31,;2.71,2.08,;2.31,3.57,;.44,3.57,;-.33,4.91,;.04,2.08,;-1.29,1.31,;-1.29,-.23,;.04,-1,;1.38,-.23,;1.38,1.31,;-2.62,2.08,;-2.62,3.62,;-3.96,4.39,;-5.29,3.62,;-5.29,2.08,;-3.96,1.31,;-3.96,-.23,;-5.29,-1,)|
Structure:
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