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Target
Bromodomain-containing protein 4 [342-460]
Ligand
BDBM318589
Substrate
n/a
Meas. Tech.
AlphaScreen Assay A2
IC50
<100±n/a nM
Citation
 Combs, AP; Sparks, RB; Maduskuie, Jr., TP; Rodgers, JD Tricyclic heterocycles as BET protein inhibitors US Patent  US10464947 Publication Date 11/5/2019 
Target
Name:
Bromodomain-containing protein 4 [342-460]
Synonyms:
BRD4 | BRD4-BD2 (aa 342-460) | BRD4_HUMAN | Bromodomain containing 4 (aa 342-460) | Bromodomain-containing protein 4 (BRD4)(BD2) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13783.81
Organism:
Homo sapiens (Human)
Description:
a.a. 342-460 (BRD4-BD2)
Residue:
119
Sequence:
PAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
  
Inhibitor
Name:
BDBM318589
Synonyms:
Single enantiomer of 3-[7-(3,5-dimethylisoxazol-4-yl)-2-oxo-1,2,4,5-tetrahydroimidazo[1,5,4-de][1,4]benzoxazin-4-yl]-N-ethylpyridine-2-carboxamide | US10464947, Example 133 | US11498926, Example 133 | US9624241, Example 133
Type:
Small organic molecule
Emp. Form.:
C22H21N5O4
Mol. Mass.:
419.4332
SMILES:
CCNC(=O)c1ncccc1C1COc2c(ccc3[nH]c(=O)n1c23)-c1c(C)noc1C |(-6.62,-1,;-5.29,-.23,;-3.96,-1,;-2.62,-.23,;-1.29,-1,;-2.62,1.31,;-3.96,2.08,;-3.96,3.62,;-2.62,4.39,;-1.29,3.62,;-1.29,2.08,;.04,1.31,;.04,-.23,;1.38,-1,;2.71,-.23,;4.04,-1,;5.38,-.23,;5.38,1.31,;4.04,2.08,;3.65,3.57,;1.78,3.57,;1.01,4.91,;1.38,2.08,;2.71,1.31,;4.04,-2.54,;2.8,-3.44,;1.47,-2.67,;3.27,-4.91,;4.81,-4.91,;5.29,-3.44,;6.62,-2.67,)|
Structure:
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