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Target
Bromodomain-containing protein 4 [42-168]
Ligand
BDBM420064
Substrate
n/a
Meas. Tech.
AlphaScreen Assay A2
IC50
<100±n/a nM
Citation
Combs, AP; Sparks, RB; Maduskuie, Jr., TP; Rodgers, JD Tricyclic heterocycles as BET protein inhibitors US Patent US10464947 Publication Date 11/5/2019
More Info.:
Target
Name:
Bromodomain-containing protein 4 [42-168]
Synonyms:
BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
15054.68
Organism:
Homo sapiens (Human)
Description:
O60885[42-168]
Residue:
127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
Inhibitor
Name:
BDBM420064
Synonyms:
US10464947, Example 176 | US11498926, Example 176 | {1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)- 4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4- de][1,4]benzoxazin-2-yl]piperidin-4- yl}methanol
Type:
Small organic molecule
Emp. Form.:
C25H27N5O3
Mol. Mass.:
445.5136
SMILES:
Cc1noc(C)c1-c1ccc2nc(N3CCC(CO)CC3)n3[C@H](COc1c23)c1ccccn1 |wU:22.31,(2.47,-4.57,;1.01,-5.05,;.53,-6.51,;-1.01,-6.51,;-1.49,-5.05,;-2.95,-4.57,;-.24,-4.14,;-.24,-2.6,;-1.57,-1.83,;-1.57,-.29,;-.24,.48,;.32,2.08,;1.86,2.08,;2.75,3.34,;2.1,4.74,;2.99,5.99,;4.52,5.86,;5.41,7.11,;4.76,8.51,;5.17,4.46,;4.28,3.2,;2.43,.48,;3.76,-.29,;3.76,-1.83,;2.43,-2.6,;1.09,-1.83,;1.09,-.29,;5.09,.48,;6.43,-.29,;7.76,.48,;7.76,2.02,;6.43,2.79,;5.1,2.02,)|