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Target
Bromodomain-containing protein 4 [42-168]
Ligand
BDBM318708
Substrate
n/a
Meas. Tech.
AlphaScreen Assay A2
IC50
<100±n/a nM
Citation
 Combs, AP; Sparks, RB; Maduskuie, Jr., TP; Rodgers, JD Tricyclic heterocycles as BET protein inhibitors US Patent  US10464947 Publication Date 11/5/2019 
Target
Name:
Bromodomain-containing protein 4 [42-168]
Synonyms:
BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
15054.68
Organism:
Homo sapiens (Human)
Description:
O60885[42-168]
Residue:
127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Inhibitor
Name:
BDBM318708
Synonyms:
N-{1-[(4S)-7-(3,5-dimethylisoxazol-4- yl)-4-pyridin-2-yl-4,5- dihydroimidazo[1,5,4- de][1,4]benzoxazin-2-yl]azetidin-3- yl}ethanesulfonamide | US10464947, Example 238 | US11498926, Example 238 | US9624241, Example 238
Type:
Small organic molecule
Emp. Form.:
C24H26N6O4S
Mol. Mass.:
494.566
SMILES:
CCS(=O)(=O)NC1CN(C1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23 |wD:26.28,(-5.65,7.05,;-4.88,5.72,;-3.34,5.72,;-3.34,7.26,;-3.34,4.18,;-1.8,5.72,;-1.03,4.38,;-1.42,2.9,;.06,2.5,;.46,3.99,;.83,1.17,;2.37,1.17,;2.93,-.27,;4.27,-1.04,;4.27,-2.58,;2.93,-3.35,;2.93,-4.89,;1.69,-5.79,;.22,-5.32,;2.16,-7.26,;3.7,-7.26,;4.18,-5.79,;5.65,-5.32,;1.6,-2.58,;.27,-3.35,;-1.07,-2.58,;-1.07,-1.04,;-2.4,-.27,;-3.73,-1.04,;-5.07,-.27,;-5.07,1.27,;-3.73,2.04,;-2.4,1.27,;.27,-.27,;1.6,-1.04,)|
Structure:
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