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Target
5'-nucleotidase
Ligand
BDBM419972
Substrate
n/a
Meas. Tech.
In Vitro Enzyme Assay
IC50
448±n/a nM
Citation
 Chen, L; Li, J; Sjogren, EB; Billedeau, RJ Ectonucleotidase inhibitors and methods of use thereof US Patent  US10472364 Publication Date 11/12/2019 
Target
Name:
5'-nucleotidase
Synonyms:
5'-NT | 5'-nucleotidase (CD73) | 5NTD_HUMAN | CD_antigen=CD73 | Ecto-5'-nucleotidase | Ecto-5-nucleotidase (e5'NT) | NT5 | NT5E | NTE
Type:
Enzyme
Mol. Mass.:
63371.54
Organism:
Homo sapiens (Human)
Description:
P21589
Residue:
574
Sequence:
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ
  
Inhibitor
Name:
BDBM419972
Synonyms:
US10472364, Compound 53 | US10570167, Cpd. # 53 | US11034715, Cpd. # 53 | US11208414, Cpd. # 53
Type:
Small organic molecule
Emp. Form.:
C21H19ClFN9O7
Mol. Mass.:
563.883
SMILES:
Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2cccc(c2)-c2nnn[nH]2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F |r|
Structure:
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