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Target
Glucagon-like peptide 1 receptor
Ligand
BDBM420033
Substrate
n/a
Meas. Tech.
GLP-1 Assay with EX-4 Synthetic Agonist
EC50
5900±n/a nM
Citation
 Lindsley, CW; Niswender, K Positive allosteric modulators of the GLP-1 receptor US Patent  US10487087 Publication Date 11/26/2019 
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP-1 receptor | GLP-1-R | GLP-1R | GLP1R | GLP1R_HUMAN | Glucagon-like peptide 1 receptor | Glucagon-like peptide 1 receptor (GLP-1)
Type:
Enzyme
Mol. Mass.:
53035.78
Organism:
Homo sapiens (Human)
Description:
P43220
Residue:
463
Sequence:
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
  
Inhibitor
Name:
BDBM420033
Synonyms:
N-(((R)-1-isopropylpyrrolidin-2-yl)methyl)-10- methyl-1-oxo-2-((S)-tetrahydrofuran-3-yl)-1,2- dihydropyrazino[1,2-a]indole-4-carboxamide | US10487087, Compound 5
Type:
Small organic molecule
Emp. Form.:
C25H32N4O3
Mol. Mass.:
436.5466
SMILES:
CC(C)N1CCC[C@@H]1CNC(=O)c1cn([C@H]2CCOC2)c(=O)c2c(C)c3ccccc3n12 |r|
Structure:
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