Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM386252
Substrate
n/a
Meas. Tech.
Measurement of Orexin Type 2 Receptor Agonist Activity
EC50
0.440±n/a nM
Citation
 Fujimoto, T; Rikimaru, K; Fukuda, K; Sugimoto, H; Matsumoto, T Substituted piperidine compound and use thereof US Patent  US10508083 Publication Date 12/17/2019 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM386252
Synonyms:
N-((2R,3S)-1-(cyclopropylcarbonyl)- 2-(((cis-4-(2,6- difluorophenyl)cyclohexyl)oxy)- methyl)piperidin-3- yl)methanesulfonamide | US10287305, Example 213 | US10508083, Example 213 | US11292766, Example 213
Type:
Small organic molecule
Emp. Form.:
C23H32F2N2O4S
Mol. Mass.:
470.573
SMILES:
CS(=O)(=O)N[C@H]1CCCN([C@H]1CO[C@H]1CC[C@H](CC1)c1c(F)cccc1F)C(=O)C1CC1 |r,wU:13.13,10.11,5.4,16.20,(6.67,1.05,;5.33,1.82,;4.56,3.16,;6.1,3.16,;4,1.05,;4,-.49,;5.33,-1.26,;5.33,-2.8,;4,-3.57,;2.67,-2.8,;2.67,-1.26,;1.33,-.49,;1.33,1.05,;,1.82,;-1.33,1.05,;-2.67,1.82,;-2.67,3.36,;-1.33,4.13,;,3.36,;-4,4.13,;-4,5.67,;-2.67,6.44,;-5.33,6.44,;-6.67,5.67,;-6.67,4.13,;-5.33,3.36,;-5.33,1.82,;1.33,-3.57,;,-2.8,;1.33,-5.11,;.56,-6.44,;2.1,-6.44,)|
Structure:
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