Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM386900
Substrate
n/a
Meas. Tech.
Measurement of Orexin Type 2 Receptor Agonist Activity
EC50
0.440±n/a nM
Citation
 Fujimoto, T; Rikimaru, K; Fukuda, K; Sugimoto, H; Matsumoto, T Substituted piperidine compound and use thereof US Patent  US10508083 Publication Date 12/17/2019 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM386900
Synonyms:
US10287305, Example 355 | US10508083, Example 355 | US11292766, Example 355 | cis-3-((cyclopropylsulfonyl)amino)- N-ethyl-2-(((cis-4- phenylcyclohexyl)oxy)methyl)- piperidine-1-carboxamide
Type:
Small organic molecule
Emp. Form.:
C24H37N3O4S
Mol. Mass.:
463.633
SMILES:
CCNC(=O)N1CCC[C@H](NS(=O)(=O)C2CC2)[C@@H]1CO[C@H]1CC[C@H](CC1)c1ccccc1 |r,wU:23.28,20.21,17.19,9.9,(-3.44,-3.46,;-2.1,-4.23,;-.77,-3.46,;.56,-4.23,;.56,-5.77,;1.9,-3.47,;3.23,-4.24,;4.56,-3.47,;4.56,-1.93,;3.23,-1.15,;3.23,.39,;4.56,1.16,;3.79,2.49,;5.33,2.49,;5.9,.39,;6.67,-.95,;7.44,.39,;1.9,-1.93,;.56,-1.16,;.56,.38,;-.77,1.15,;-2.1,.39,;-3.44,1.15,;-3.44,2.69,;-2.1,3.46,;-.77,2.69,;-4.77,3.46,;-4.77,5,;-6.1,5.77,;-7.44,5,;-7.44,3.46,;-6.1,2.69,)|
Structure:
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