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Target
Tumor necrosis factor
Ligand
BDBM296839
Substrate
n/a
Meas. Tech.
TNF or CD40L-Induced HEK-Blue Assay
IC50
<1000±n/a nM
Citation
 Marcin, LR; Wrobleski, ST; Dhar, TM Heterocyclic compounds useful as inhibitors of TNF US Patent  US10112944 Publication Date 10/30/2018 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM296839
Synonyms:
1-(2-(Difluoromethoxy)phenyl)-8-(1-methyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroimidazo[1,2-a:5,4-b′]dipyridine | US10112944, Example 13
Type:
Small organic molecule
Emp. Form.:
C21H19F2N5O
Mol. Mass.:
395.4053
SMILES:
Cn1cc(cn1)-c1ccc2nc3CCCN(c3n2c1)c1ccccc1OC(F)F
Structure:
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