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Target
Tumor necrosis factor
Ligand
BDBM296841
Substrate
n/a
Meas. Tech.
TNF or CD40L-Induced HEK-Blue Assay
IC50
<1000±n/a nM
Citation
 Marcin, LR; Wrobleski, ST; Dhar, TM Heterocyclic compounds useful as inhibitors of TNF US Patent  US10112944 Publication Date 10/30/2018 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM296841
Synonyms:
4-(5-(1-(2-(Difluoromethoxy)phenyl)-1,2,3,4-tetrahydroimidazo[1,2-a:5,4-b′]dipyridin-8-yl)pyrimidin-2-yl)morpholine | US10112944, Example 15
Type:
Small organic molecule
Emp. Form.:
C25H24F2N6O2
Mol. Mass.:
478.4939
SMILES:
FC(F)Oc1ccccc1N1CCCc2nc3ccc(cn3c12)-c1cnc(nc1)N1CCOCC1
Structure:
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