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Target
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Ligand
BDBM261608
Substrate
n/a
Meas. Tech.
spectrophotometrical in vitro assay
IC50
25.0±n/a nM
Citation
 Pellicciari, R; Auwerx, J; Raffaelli, N Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase US Patent  US10513499 Publication Date 12/24/2019 
Target
Name:
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Synonyms:
ACMSD | ACMSD_HUMAN | Picolinate carboxylase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38037.38
Organism:
Homo sapiens (Human)
Description:
Q8TDX5
Residue:
336
Sequence:
MKIDIHSHILPKEWPDLKKRFGYGGWVQLQHHSKGEAKLLKDGKVFRVVRENCWDPEVRIREMDQKGVTVQALSTVPVMFSYWAKPEDTLNLCQLLNNDLASTVVSYPRRFVGLGTLPMQAPELAVKEMERCVKELGFPGVQIGTHVNEWDLNAQELFPVYAAAERLKCSLFVHPWDMQMDGRMAKYWLPWLVGMPAETTIAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTVGRISHGFSMRPDLCAQDNPMNPKKYLGSFYTDALVHDPLSLKLLTDVIGKDKVILGTDYPFPLGELEPGKLIESMEEFDEETKNKLKAGNALAFLGLERKQFE
  
Inhibitor
Name:
BDBM261608
Synonyms:
US10513499, Compound 19 | US11254644, Compound 19 | US9708272, 19
Type:
Small organic molecule
Emp. Form.:
C18H11N5O3S2
Mol. Mass.:
409.442
SMILES:
O=c1[nH]c(no1)-c1cccc(CSc2nc(-c3cccs3)c(C#N)c(=O)[nH]2)c1
Structure:
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