Target
MAP kinase-interacting serine/threonine-protein kinase 1
Ligand
BDBM297344
Substrate
n/a
Meas. Tech.
MNK Biochemical Enzymatic Assay
IC50
<10±n/a nM
Citation
 Sprengeler, PAReich, SHErnst, JTWebber, SEShaghafi, MMurphy, DTran, C Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of Mnk1 and Mnk2 US Patent  US10112955 Publication Date 10/30/2018 
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 1
Synonyms:
MAP Kinase-Interacting Protein Kinase (MNK1) | MAP kinase signal-integrating kinase 1 | MAP kinase-interacting serine/threonine-protein kinase 1 (MnK1) | MAP kinase-interacting serine/threonine-protein kinase MNK1 | MAP-kinase interacting kinase 1 (MNK1) | MAPK signal-integrating kinase 1 | MKNK1 | MKNK1_HUMAN | MNK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
51342.85
Organism:
Homo sapiens (Human)
Description:
Q9BUB5
Residue:
465
Sequence:
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
  
Inhibitor
Name:
BDBM297344
Synonyms:
N-(6-((1-oxoisoindolin-5-yl)amino)pyrimidin-4-yl)acetamide (Cpd. No. 11) | US10112955, Example 11
Type:
Small organic molecule
Emp. Form.:
C14H13N5O2
Mol. Mass.:
283.2853
SMILES:
CC(=O)Nc1cc(Nc2ccc3C(=O)NCc3c2)ncn1
Structure:
Search PDB for entries with ligand similarity: