Reaction Details Report a problem with these data
Target
MAP kinase-interacting serine/threonine-protein kinase 1
Ligand
BDBM297368
Substrate
n/a
Meas. Tech.
MNK Biochemical Enzymatic Assay
IC50
550±n/a nM
Citation
 Sprengeler, PA; Reich, SH; Ernst, JT; Webber, SE; Shaghafi, M; Murphy, D; Tran, C Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of Mnk1 and Mnk2 US Patent  US10112955 Publication Date 10/30/2018 
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 1
Synonyms:
MAP Kinase-Interacting Protein Kinase (MNK1) | MAP kinase signal-integrating kinase 1 | MAP kinase-interacting serine/threonine-protein kinase 1 (MnK1) | MAP kinase-interacting serine/threonine-protein kinase MNK1 | MAP-kinase interacting kinase 1 (MNK1) | MAPK signal-integrating kinase 1 | MKNK1 | MKNK1_HUMAN | MNK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
51342.85
Organism:
Homo sapiens (Human)
Description:
Q9BUB5
Residue:
465
Sequence:
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
  
Inhibitor
Name:
BDBM297368
Synonyms:
5-(7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazin-4-ylamino)-3-methyl-isoindolin-1-one (Cpd. No. 38) | US10112955, Example 38
Type:
Small organic molecule
Emp. Form.:
C15H15N5O2
Mol. Mass.:
297.3119
SMILES:
CC1NC(=O)c2ccc(Nc3ncnc4NCCOc34)cc12
Structure:
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