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Target
MAP kinase-interacting serine/threonine-protein kinase 2
Ligand
BDBM297371
Substrate
n/a
IC50
5050±n/a nM
Citation
 Sprengeler, PA; Reich, SH; Ernst, JT; Webber, SE; Shaghafi, M; Murphy, D; Tran, C Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of Mnk1 and Mnk2 US Patent  US10112955 Publication Date 10/30/2018 
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 2
Synonyms:
GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2
Type:
Protein
Mol. Mass.:
51870.79
Organism:
Homo sapiens (Human)
Description:
Q9HBH9
Residue:
465
Sequence:
MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAGQGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
  
Inhibitor
Name:
BDBM297371
Synonyms:
4-[(3-methyl-1-oxo-isoindolin-5-yl)amino]-5,7-dihydropyrrolo[2,3-d]pyrimidin-6-one (Cpd. No. 41) | US10112955, Example 41
Type:
Small organic molecule
Emp. Form.:
C15H13N5O2
Mol. Mass.:
295.296
SMILES:
CC1NC(=O)c2ccc(Nc3ncnc4NC(=O)Cc34)cc12
Structure:
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