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Target
MAP kinase-interacting serine/threonine-protein kinase 2
Ligand
BDBM297380
Substrate
n/a
IC50
<10±n/a nM
Citation
 Sprengeler, PA; Reich, SH; Ernst, JT; Webber, SE; Shaghafi, M; Murphy, D; Tran, C Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of Mnk1 and Mnk2 US Patent  US10112955 Publication Date 10/30/2018 
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 2
Synonyms:
GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2
Type:
Protein
Mol. Mass.:
51870.79
Organism:
Homo sapiens (Human)
Description:
Q9HBH9
Residue:
465
Sequence:
MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAGQGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
  
Inhibitor
Name:
BDBM297380
Synonyms:
6'-((6-aminopyrimidin-4-yl)amino)-4'-methylspiro[cyclohexane-1,1'isoindolin]-3'-one (Cpd. No. 51) | US10112955, Example 51
Type:
Small organic molecule
Emp. Form.:
C18H21N5O
Mol. Mass.:
323.3922
SMILES:
Cc1cc(Nc2cc(N)ncn2)cc2c1C(=O)NC21CCCCC1
Structure:
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