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Target
Prostaglandin F2-alpha receptor
Ligand
BDBM297434
Substrate
n/a
Meas. Tech.
In Vitro Test of Inhibition of Human FP Receptor Activity
IC50
129±n/a nM
Citation
 Beck, H; Thaler, T; Kast, R; Meininghaus, M; Terjung, C; Muenster, U; Olenik, B Substituted N-bicyclo-2-aryl-quinolin-4-carboxamides and use thereof US Patent  US10117864 Publication Date 11/6/2018 
Target
Name:
Prostaglandin F2-alpha receptor
Synonyms:
PF2R_HUMAN | PGF receptor | PGF2 alpha receptor | PGF2-alpha receptor | PTGFR | Prostaglandin F | Prostanoid FP receptor
Type:
Enzyme
Mol. Mass.:
40072.29
Organism:
Homo sapiens (Human)
Description:
P43088
Residue:
359
Sequence:
MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
  
Inhibitor
Name:
BDBM297434
Synonyms:
4-({[6-Bromo-3-methyl-2-(2-methylphenyl)quinolin-4-yl]carbonyl}amino)bicyclo[2.2.2]octane-1-carboxylic acid | US10117864, Example 24
Type:
Small organic molecule
Emp. Form.:
C27H27BrN2O3
Mol. Mass.:
507.419
SMILES:
Cc1ccccc1-c1nc2ccc(Br)cc2c(C(=O)NC23CCC(CC2)(CC3)C(O)=O)c1C
Structure:
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