Reaction Details Report a problem with these data
Target
Prostaglandin F2-alpha receptor
Ligand
BDBM297477
Substrate
n/a
Meas. Tech.
In Vitro Test of Inhibition of Human FP Receptor Activity
IC50
440±n/a nM
Citation
 Beck, H; Thaler, T; Kast, R; Meininghaus, M; Terjung, C; Muenster, U; Olenik, B Substituted N-bicyclo-2-aryl-quinolin-4-carboxamides and use thereof US Patent  US10117864 Publication Date 11/6/2018 
Target
Name:
Prostaglandin F2-alpha receptor
Synonyms:
PF2R_HUMAN | PGF receptor | PGF2 alpha receptor | PGF2-alpha receptor | PTGFR | Prostaglandin F | Prostanoid FP receptor
Type:
Enzyme
Mol. Mass.:
40072.29
Organism:
Homo sapiens (Human)
Description:
P43088
Residue:
359
Sequence:
MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
  
Inhibitor
Name:
BDBM297477
Synonyms:
4-{[(6-Bromo-2-phenyl-3-vinylquinolin-4-yl)carbonyl]amino}bicyclo[2.2.2]octane-1-carboxylic acid | US10117864, Example 67
Type:
Small organic molecule
Emp. Form.:
C27H25BrN2O3
Mol. Mass.:
505.403
SMILES:
OC(=O)C12CCC(CC1)(CC2)NC(=O)c1c(C=C)c(nc2ccc(Br)cc12)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: