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Target
RAC-alpha serine/threonine-protein kinase [E17K]
Ligand
BDBM431882
Substrate
n/a
Meas. Tech.
Biochemical Assays
IC50
952±102 nM
Citation
 Rauh, D; Gontla, R; Weisner, J Kinase inhibitors and their use in cancer therapy US Patent  US10550114 Publication Date 2/4/2020 
Target
Name:
RAC-alpha serine/threonine-protein kinase [E17K]
Synonyms:
AKT1 | AKT1_HUMAN | PKB | RAC | RAC-alpha serine/threonine-protein kinase AKT1 (E17K)
Type:
Enzyme
Mol. Mass.:
55682.32
Organism:
Homo sapiens (Human)
Description:
P31749 (E17K)
Residue:
480
Sequence:
MSDVAIVKEGWLHKRGKYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
  
Inhibitor
Name:
BDBM431882
Synonyms:
US10550114, Compound 46
Type:
Small organic molecule
Emp. Form.:
C37H34N6O3
Mol. Mass.:
610.7043
SMILES:
Cn1c2ccc(NC(=O)C=C)cc2n(C2CCN(Cc3ccc(cc3)-c3nc4cc[nH]c(=O)c4cc3-c3ccccc3)CC2)c1=O
Structure:
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