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Target
RAC-alpha serine/threonine-protein kinase [E17K]
Ligand
BDBM50313650
Substrate
n/a
Meas. Tech.
Biochemical Assays
IC50
3489±434 nM
Citation
 Rauh, D; Gontla, R; Weisner, J Kinase inhibitors and their use in cancer therapy US Patent  US10550114 Publication Date 2/4/2020 
Target
Name:
RAC-alpha serine/threonine-protein kinase [E17K]
Synonyms:
AKT1 | AKT1_HUMAN | PKB | RAC | RAC-alpha serine/threonine-protein kinase AKT1 (E17K)
Type:
Enzyme
Mol. Mass.:
55682.32
Organism:
Homo sapiens (Human)
Description:
P31749 (E17K)
Residue:
480
Sequence:
MSDVAIVKEGWLHKRGKYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
  
Inhibitor
Name:
BDBM50313650
Synonyms:
8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one | CHEMBL1079175 | MK-2206 | US10550114, Compound MK-2206
Type:
Small organic molecule
Emp. Form.:
C25H21N5O
Mol. Mass.:
407.4671
SMILES:
NC1(CCC1)c1ccc(cc1)-c1nc2ccn3c(n[nH]c3=O)c2cc1-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: