Reaction Details Report a problem with these data
Target
Casein kinase II subunit alpha'
Ligand
BDBM431900
Substrate
n/a
IC50
<10±n/a nM
Citation
 Purandare, AV; Zimmermann, K; Wan, H Prodrugs of imidazotriazine compounds as CK2 inhibitors US Patent  US10550125 Publication Date 2/4/2020 
Target
Name:
Casein kinase II subunit alpha'
Synonyms:
CK2A2 | CSK22_HUMAN | CSNK2A2 | Casein kinase II alpha (prime) | Casein kinase II alpha' | Casein kinase II subunit alpha (CK2A2) | Casein kinase II subunit alpha (CSNK2A2)
Type:
Protein
Mol. Mass.:
41223.82
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
350
Sequence:
MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR
  
Inhibitor
Name:
BDBM431900
Synonyms:
US10550125, Example 4
Type:
Small organic molecule
Emp. Form.:
C30H37ClN11O9P
Mol. Mass.:
762.11
SMILES:
CCNc1nc(nn2c(cnc12)C#N)N(C(=O)OCOC(=O)CC(C)(C)COP(O)(O)=O)c1cc(cc(N2CCN(CC2)[C@@H](C)C(N)=O)c1Cl)C#N |r|
Structure:
Search PDB for entries with ligand similarity: